故事以只有女性能使用的世界最強兵器「Infinite Stratos(IS)」為中心,在女尊男卑的世界中,主角「織斑一夏」雖然身為男生卻能夠操縱 IS,為此他被強制進入培育 IS 操縱者的學校「IS 學園」,周圍理所當然也都是女性,而女生們也對這位「世上唯一能夠使用 IS 的男性」感到興趣,就此展開了許多趣味橫生的學校生活。
The Anti-Monitor (the Monitor's evil counterpart) is released in the DC Multiverse and begins to destroy the different Earths huo87.com that compose it. The Monitor attempts to recruit heroes from across the Multiverse, but is murdered.