Luke(杰克·约翰逊 Jake M. Johnson 饰)和Kate(奥利维亚·王尔德 Olivia Wilde 饰)是一对好朋友,两人在同一个酿酒厂工作,亲密无间,堪称知己。同时Luke有一个相恋多年谈婚论嫁的女友Jill(安娜·肯德里克 Anna Kendrick 饰),而Kate也有一个男友Chris(朗·里维斯顿 Ron Livingston 饰)。四人相识之后便经常进行四人约会。不久,Chris提出了分手,Kate开始了放荡的生活,Luke不忍看Kate日渐消沉,然而只是朋友的他又能做些什么呢?
When Will Ferrell finds out his close friend of 30 years is coming out as a trans woman, the two decide to embark on a cross-country road trip to process this new stage of their relationship in an intimate portrait of friendship, transition, and America.
Isolated on the fringes of a soulless metropolis, Catherine survives on scraps of translation work. But a mysterious client offers a lucrative job, and an opportunity for Catherine to indulge in her malformed and incompatible desires.