While on a botanical expedition in Tibet Dr. Wilfred Glendon is attacked in the dark by a strange animal. Returning to London, he finds himself turning nightly into a werewolf and terrorizing the city, with the only hope for curing his affliction a rare Asian flower.
When Will Ferrell finds out his close friend of 30 years is coming out as a trans woman, the two decide to embark on a cross-country road trip to process this new stage of their relationship in an intimate portrait of friendship, transition, and America.
Isolated on the fringes of a soulless metropolis, Catherine survives on scraps of translation work. But a mysterious client offers a lucrative job, and an opportunity for Catherine to indulge in her malformed and incompatible desires.