A young couple Mira (Abbie Cobb) and Todd (Sean Faris) hire a live-in nurse (Lyndon Smith) to be the caregiver for their sick son, only to discover that she is an angel of death intent on replacing Mira through any means necessary.
When Will Ferrell finds out his close friend of 30 years is coming out as a trans woman, the two decide to embark on a cross-country road trip to process this new stage of their relationship in an intimate portrait of friendship, transition, and America.
Isolated on the fringes of a soulless metropolis, Catherine survives on scraps of translation work. But a mysterious client offers a lucrative job, and an opportunity for Catherine to indulge in her malformed and incompatible desires.