Special Agent Alexander Connor is sent to investigate a house, from which a woman named Sandra has made numerous 911 calls. Things become more complicated than expected for Agent Connor, as he finds he must also rescue a police officer who responded to the home 24 hours earlier. Soon, Agent Connor will discover a horrifying secret; that Sandra is one of LUMEN CORPORATION's donors and has devoted her house to the corporation; a house which has been turned into a research lab for atrocious experiments performed on human beings.
When Will Ferrell finds out his close friend of 30 years is coming out as a trans woman, the two decide to embark on a cross-country road trip to process this new stage of their relationship in an intimate portrait of friendship, transition, and America.
Isolated on the fringes of a soulless metropolis, Catherine survives on scraps of translation work. But a mysterious client offers a lucrative job, and an opportunity for Catherine to indulge in her malformed and incompatible desires.