塔克中尉(丹尼斯·奎德 Dennis Quaid 饰)性格冲动,蔑视威权,但他同时是开发缩微飞行器技术的“阿尔法计划”的主驾驶员。塔克酒后胡作非为导致记者女友莉迪亚(梅格·瑞恩 Meg Ryan 饰)愤怒离去,当日的工作则同样遭遇了挫折——一群匪徒闯入研究中心,试图将研制中的缩微飞行器芯片夺走,研究员为了保住芯片,将已经进入缩微状态的塔克和飞行器注入了一名路人杰克(马丁·肖特 Martin Short 饰)的屁股,杰克是一名神经过敏的超市收银员,塔克在杰克的身体内部游走,帮助其躲过匪徒的追踪后返回研究中心求助,然而中心为利益决定放弃杰克体内的塔克,二人无奈只得自救,他们向莉迪亚求助,想要在塔克的氧气耗尽前夺回被抢走的芯片,令塔克恢复原来的大小……
When Will Ferrell finds out his close friend of 30 years is coming out as a trans woman, the two decide to embark on a cross-country road trip to process this new stage of their relationship in an intimate portrait of friendship, transition, and America.
Isolated on the fringes of a soulless metropolis, Catherine survives on scraps of translation work. But a mysterious client offers a lucrative job, and an opportunity for Catherine to indulge in her malformed and incompatible desires.