Jonathan is a very lonely man. One day, he gets a visitor in his house: a young woman who, through a jarring turn of events, ends up dead. He does not report it because he is happy to have a friend, but now the body begins to decay.
When Will Ferrell finds out his close friend of 30 years is coming out as a trans woman, the two decide to embark on a cross-country road trip to process this new stage of their relationship in an intimate portrait of friendship, transition, and America.
Isolated on the fringes of a soulless metropolis, Catherine survives on scraps of translation work. But a mysterious client offers a lucrative job, and an opportunity for Catherine to indulge in her malformed and incompatible desires.